The availability of fatty acids is the key to longevity

For years, science has advocated very little fat, but the discovery of safflower changed that. And it all starts with dolphins

Supplements often have interesting stories about the origin of the molecules of vegetables that we eat regularly (sulforaphane) or are named after what was first discovered in (spermidine) but C15:0 beats them down. Or the folds are on the bottom..?

The story begins when zoologist Dr Stephanie Venn-Watson was working to improve the health of ancient dolphins as part of the US Navy Marine Mammal Program; studying the health of the Navys long-lived, large-brained dolphins, made the remarkable discovery that the dolphin pods in Florida had a slower aging rate than the dolphins in California. Venn-Watson found the saturated fat in the dolphins’ whole fish diet predicted better health in older people, and increasing the dolphins’ diet of this saturated fat reduced anemia. [1]a sign of the rapid aging of dolphins [2]and age-related stability, with researchers seeing a 72% change in cellular stability [3]. This led him to discover the essential oil found in the 90s C15:0.

Longevity.Technology: Age-related conditions that reduce C15:0 in dolphins are similar to those that lead to diabetes, heart disease and stroke in humans. So, what makes C15:0 so effective? C15:0 is a fatty acid, like omega-3 and omega-6, but unlike them, C15:0 does not have two bonds in its main chain, which makes it a stable molecule that is resistant to oxidation. [4]. C15:0 is an odd saturated fatty acid type that is consistently associated with a lower risk of type 2 diabetes, heart disease and fatty liver disease. [4]. This all sounds great, but the catch is that we don’t make C15:0, so we need to get enough from our diet or through supplements.

We had to find out more about C15:0 and this new fat-based supplement, so we sat down with Stephanie Venn-Watson, DVM, MPH, Co-Founder and CEO of fatty15 and Eric Venn-Watson, MD, MBA, Co-Founder and COO of fatty15.

Fatty acids have been used by demons for many years; After raising the red flag for saturated fat in our diets 40 years ago, health programs and experts recommended avoiding it, but instead of seeing better global health, says Venn-Watsons, there has been a rise in type 2 diabetes. , heart disease, liver disease and specific types of cancer, especially among young people.

Advanced science now supports that we accidentally created a nutritional deficiency of C15:0, a healthy and essential fat, explains Stephanie Venn-Watson. Also, C15:0 deficiency can increase our risk of getting the diseases we are trying to avoid.

It’s good to be odd; Venn-Watson explains that even-chain-saturated fatty acids have carbon atoms, and fatty acids (especially C16:0 and C18:0) are always associated with negative health symptoms that make us avoid saturated fat.

These health markers include increased risk of heart disease, inflammation and type 2 diabetes, he says. Even-chain saturated fatty acids are found in red meat, full-fat dairy, and palm oil.

Odd-chain saturated fatty acids, however, have unnumbered carbon atoms in their molecular structure and are linked by on the ground risk of heart disease, inflammation, and type 2 diabetes. Odd-chain saturated fatty acids, including C15:0 and C17:0, can be found in the same foods as even-chain-saturated fatty acids, which makes it difficult getting the good stuff full of fatty acids without the bad.

Eric Venn-Watson adds that the decrease in the number of people who consume high-fat milk has caused the C15: 0 to be very low, which is associated with an increase in many chronic diseases. In addition, C15:0 levels decrease with age, which may promote aging.

Although the global number of people with type 2 diabetes (537 million), heart disease (523 million), and cancer (18 million) is high, this is expected to continue to increase without effective, accessible, and safe interventions. , and safe. relevant to many people, he explains. Science so far supports that restoring C15:0 levels can help restore global health.

Old age is a double-edged sword; as we age, our cells can be damaged but repair becomes less and easier. How can C15:0 help? Because it is a stable fat that easily enters our cells, C15:0 can make our cells more resistant to damage; Evolution has used fatty acids in the membranes of cells to help them live longer, a theory called the Cell Membrane Pacemaker Theory of Aging that explains why albatross live longer than chickens and why humans and dolphins live longer than mice. [5].

In addition to stabilizing cell membranes, C15:0 reduces many signs of aging, including cell senescence, inflammation, mitochondrial dysfunction and poor cell transcription, explains Stephanie Venn-Watson. Specifically, pure C15:0 fatty acids in fat15 have been shown in peer-reviewed studies to strengthen cell membranes, improve mitochondrial function and regulate cell signaling (including activating PPAR/ and AMPK receptors and inhibiting mTOR) these are well-established goals. Reduces inflammation, regulates blood sugar, stabilizes blood cells, and reduces the number of cancer cells.

Although fat15 is designed to support the metabolism, heart, liver and immune system, and is not intended as a supplement or replacement for fat-loss drugs, Eric Venn-Watson explains that about half of people who take fat15 increase energy. throughout the day, sleeping well, or eating less between meals within two weeks.

In addition, C15:0 naturally activates key receptors and pathways, including PPARs and AMPK, which help regulate cholesterol and glucose metabolism, he says. This helps to explain why the daily amount of fat helped to promote and maintain healthy blood sugar and cholesterol homeostasis in the right conditions, and why the amount of C15:0 in people has been associated with good health.

In the post-COVID world, people are looking for supplements that can boost the immune system, but, as Eric Venn-Watson explains, efficiency is key.

As we age, our immune system begins to overreact, which leads to chronic inflammation, which causes inflammation, he explains, referring to inflammation, a major symptom of aging that causes the onset or progression of many chronic diseases, including type 2 diabetes and heart disease. . Pure C15: 0 synthetic fat15 reduces 18+ pro-inflammatory cytokines to help reduce the immune response and keep our immune system healthy.

Venn-Watsons is eager to spread the word about the newly discovered member of the essential fatty acid family and is launching an educational effort to increase healthcare providers and consumers’ awareness of C15:0, discuss the science behind fatty15 and explain how fatty15 can provide essential nutrients. This is to support long-term health and wellness. In addition, Seraphina will be promoting oil15 as a food and drink to support healthy aging.

There is also a randomized, double-blind and placebo-controlled clinical trial of oil15 being conducted at the University of California San Diego and Rady Childrens Hospital. [6]and fatty15 are followed by three leading patients with long-term survival (rapamycin, metformin and acarbose), using a molecular phenotypic profile.

[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230769
[2] https://www.pnas.org/doi/10.1073/pnas.1918755117
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399118/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/
[5] https://pubmed.ncbi.nlm.nih.gov/15757684/
[6] https://clinicaltrials.gov/study/NCT04947176

Photo: nualaimages/Envato / Seraphina Therapeutics